Cerebral ischemia can cause neuronal injury,and effect nerve function . Neural stem cells (NSCs) can proliferate and differentiate into new neurons under certain conditions, Which involved in the repair of neurological function after cerebral ischemia. In this paper, Review the mechanism of the components and modulators in the Wnt signaling pathway，the effect of Wnt pathway，the neurogenic factors and promoting neurogenesis factors on the neurogenesis.