Objective: To review the methods of stress model in tumor-bearing animal, and to analyze the perspective of the stress in tumor development role mechanism. Methods: A computer-based online search was performed using key words of “stress, animal model, murine, and evaluate” for documents on VIP and PuMed from 2000 to 2013. Repetitive papers were excluded. Results: A total of 596 documents were collected, including 156 in Chinese and 440 in English. By reading titles and abstract, 30 papers were included in the final analysis. Conclusion: It is provided a new approach to further explore the stress in tumor pathogenesis mechanisms, and screening antitumor drugs.