Systemic lupus erythematosus(SLE) is characterized by the presence of anti-nuclear antibodies (ANA) directed against naked DNA and entire nucleosomes. Systemic lupus erythematosus is a multifactorial autoimmune disease that affected by genetic, environmental, hormonal, infection factors. But mice with lupus nephritis model and SLE pathogenesis and pathological changes have similar characteristics to human in SLE, which is an ideal experimental pathological model for the study of SLE and screening of anti-inflammatory-immunity drugs. In this article we have reviewed lupus nephritis mouse model preparation methods and evaluations. This would be of its significance through the comparison of murine lupus nephritis model specific methods and evaluation of characteristics.