The irritable bowel syndrome (IBS) is a common disorder of unknown etiology. A group of dysregulated microRNAs (miRNAs) in blood microvesicles and in colon tissue have been identified in IBS patients. Research on miRNA, first phase may serve as a new way to further understand the pathophysiology of IBS characteristics, and eventually will leads us to use new strategy for diagnosis and treatment of IBS method by using miRNAs. Currently, there is not a lot of study with the role of miRNA in IBS. This paper summarize the work about miRNA on IBS.