The development of the apparatus for Object Recognition Task in rats
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    Abstract:

    【Abstract】 Object Developing the apparatus for Object Recognition Task(ORT) in rats to evaluate recognitive behaviour activities in the rat. Methods Combing the advantage of mechanical engineering and animal behaviour developed the closed apparatus stimulating the nature environment for ORT in rats and validated its feasibility with ORT in rats. Results Both of 230±10g rats in the closed apparatus and open-field apparatus could discriminate the familiar object from the novel one in the test phase(P<0.01, P<0.05). Moreover,the relative discrimination index was significantly different from the chance level(0)in the closed apparatus groups(P<0.01),the total exploration time for the objects in the test phase,and the absolute discrimination index of rats in the closed apparatus group were significant, if compared with open-field apparatus group(P<0.05),however, the relative discrimination index was not significant.Meanwhile,both of male Wistar rats (230±10g and 340±10g) could discriminate the familiar object from the novel object in the test phase(P<0.01).The relative discrimination index was significantly different from the chance level(0)in the two groups(P<0.01, P<0.05), but there was not significant, if compared with each other. Conclusion The normal rats in the closed apparatus could discriminate the familiar object from the novel one in the test phase,performing the memory for the familiar object ,but the exploration level was better than the open-field group.The new closed apparatus stimulating the nature environment was the same as the open-field apparatus being used for ORT in rats .

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History
  • Received:January 04,2013
  • Revised:March 28,2013
  • Adopted:July 25,2013
  • Online: August 29,2013
  • Published: