Acute myocardial infarction (AMI) can cause dramatic remodeling of the heart function and structure. These effects not only exist in the infarcted area, but also in the non-infarcted area. Myocardial dysfunction in the non- infarcted zone widely exists in patients with myocardial infarction, and the abnormal function of the non-infarcted area is an important predictor for the prognosis of AMI patients. Several related clinical and animal studies have also suggested that the regulation of non-infarcted areas is important to maintain cardiac function. Hence, studies on the manifestation, mechanism, and treatment of myocardial dysfunction in the non-infarcted area can provide valuable insights and guidance for myocardial function preservation in myocardial infarction patients. We reviewed the clinical and animal studies related to non-infarcted myocardium after acute myocardial infarction to provide ideas for the treatment and new intervention ideas of AMI .