Atherosclerosis is the common pathogenesis of many acute and chronic cardiovascular and cerebrovascular diseases, which are affected by a wide range of people. In recent years, Chinese medicine has played an important role in the prevention and treatment of atherosclerosis, and in-depth exploration of the pharmacological mechanism of traditional Chinese medicine in the treatment of atherosclerosis is beneficial to guide clinical drug use and new drug development. Therefore, it is urgent to establish accurate animal model of atherosclerosis combining disease and syndrome. This paper reviews the research progress of animal models of atherosclerosis combining disease and syndrome to provide basis for animal models of traditional Chinese medicine experimental research.