Diabetes mellitus is a metabolic disease that is characterized by high blood sugar levels. Chronic hyperglycemia in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. These complications often threaten the life of patients. Therefore, there is an urgent requirement for safe and effective drugs to intervene in diabetic complications. Astragali radix is a common tonic in Chinese medicine and one of the main components of many anti-diabetes treatments using Chinese herbal compounds. Astragali radix is rich in polysaccharides (APS), saponins (ASS), flavones (ASF), and other anti-diabetes components, which have a good effect on the complications of diabetes. In this article, literature on the complications and mechanism of Astragali radix for intervention in diabetes in recent years is reviewed to provide a reference for future studies on complications of intervention by Astragali radix in diabetes.