Ischemic stroke is still a heavy burden due to its higher incidence and mortality rate. Therapeutic hypothermia is considered as the most promising treatment for ischemic stroke. However, there is still an uncertain efficacy in clinical trials despite evidence of efficacy in pre-clinical experiments. Nonhuman primates serve as the bridge between pre-clinical and clinical studies. We summarize recent progress of therapeutic hypothermia in stroke models of nonhuman primates. We want to promote the translation of therapeutic hypothermia in clinical trials.