Objective To detect changes in serum lipid levels due to serum uric acid-lowering therapy in spontaneously hypertensive rats with hyperuricemia. Methods Experimental rats were divided into five groups. The control group (A1; spontaneously hypertensive rats; 10 males, 10 females ) was administered the same volume of 0. 5% carboxymethyl cellulose sodium for 2 weeks. The spontaneously hypertensive rats with hyperuricemia group (B1; 15 males, 15 females) was administered adenine ( 150 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) and ethambutol (250 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) for 2 weeks. The control / continuing established animal model group (A2; spontaneously hypertensive rats; 5 males and 5 females randomly chosen from A1) received the same volume of 0. 5% carboxymethyl cellulose for 4 weeks. The spontaneously hypertensive rats with hyperuricemia / continuing established animal model group (B2; 5 males and 5 females randomly chosen from B1) were administered adenine (150 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) and ethambutol (250 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) for 5 weeks. The spontaneously hypertensive rats+hyperuricemia+serum uric acid-lowering therapy group (B3; 5 males and 5 females randomly chosen from B1) were administered adenine ( 150 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) and ethambutol ( 250 mg / kg dissolved in 0. 5% carboxymethyl cellulose sodium) and allopurinol (10 mg / kg Solved in 0. 5% Carboxymethyl cellulose-Na ) for 5 weeks. animal esperment in 2,4 and 7 weeks, before starting the experiment, the serum levels of uric acid, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol were tested using microplate readers. Results Serum uric acid levels and serum lipids in the experimental group differed significantly from those of the control group ( P<0. 05). Conclusions Serum uric acid-lowering therapy for spontaneously hypertensive rats with hyperuricemia altered the serum lipid levels.