Objective To induce a hyperlipidemic animal model by feeding Sprague-Dawley (SD) rats a high-fat diet, explore the variation in relevant indicators by comparing the difference between 8 and 14 days of modeling, and provide a reference for the establishment of animal models to facilitate the evaluation of hypolipidemic agents. Methods Models were established in 8 and 14 days under the same environmental conditions according to the same standards. Seventy-two male SD rats were randomly divided into the model and control groups. Model feed was given to the model groups, and maintenance feed was given to the control groups. The indicators of hyperlipidemia were evaluated in the established SD models. Results The total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in the model group were significantly higher than those in the control group (P< 0. 01). High-density lipoprotein cholesterol was lower than that in the control group (P< 0. 01). The correlation trend of each index between the two model groups was highly consistent. Similarly, the correlation trend of each index between the two control groups was highly consistent. However, the correlation between the model group and the control group was quite different. The serum triglyceride and high-density lipoprotein levels in the two model groups were significantly different (P< 0. 01). Liver pathological changes of different degrees were observed 8 and 14 days after modeling. Conclusions Hyperlipidemia models were successfully induced in both 8 and 14 days. They were both mixed hyperlipidemia models. The method used in this study is feasible, stable, and reproducible.