Objective To evaluate the accuracy of high-frequency ultrasound in detecting myocardial damage and cervical vascular lesions caused by liver cirrhosis in rats. Methods Rats were divided into a model group and a control group. After 9 weeks, the cardiac function and common carotid artery-related indicators were detected in the two groups, and HE staining was used to observe the pathological morphological changes of the liver, heart, and common carotid artery. Pearson’ s correlation coefficient was used to analyze the correlation between the actual left ventricular weight (LVM), ultrasound LVM, common carotid artery wall thickness determined by ultrasound, and actual thickness of HE staining common carotid intima. Results The structures of the liver, myocardial tissue, and common carotid artery in the control group were normal. In contrast, we observed false leaflets, disorganized liver cells, absent or edged central veins, various degrees of liver cell degeneration and inflammatory cell infiltration, and a loose and swollen structure of myocardial cells in the model group. In addition, myocardial fibers were disorganized, broken, and infiltrated by inflammatory cells, the extracellular matrix was increased, the inner wall of the common carotid artery was thicker, and the lumen was narrowed and reduced in size. The actual LVM and measured of HE staining common carotid artery intima in the model group were greater than those in the control group (P< 0. 05). The left ventricular end-diastolic diameter, left ventricular end-systolic diameter, left ventricular end-diastolic volume, LVM, and heart rate in the model group were higher than that in the control group, and fraction shortening was lower in the model group than in the control group (P< 0. 05). The carotid artery inner diameter, tube wall thickness, and blood flow velocity were reduced compared with the control group, and the pulsation index and resistance index were higher in the model group than in the control group (P< 0. 05). Pearson’ s correlation analysis showed that the ultrasound LVM was positively correlated with the measured LVM ( r= 0. 875, P< 0. 001), and the ultrasound-measured carotid artery wall thickness was positively correlated with the measured thickness of HE-stained common carotid intima (r= 0. 821, P< 0. 001). Conclusions Using high-frequency ultrasound to evaluate myocardial damage and cervical vascular lesions in liver cirrhosis rats provides accurate and reliable result , highlighting its potential use in clinical applications.