Abstract:Rheumatoid arthritis (RA) is a common autoimmune disease with high disability, and its pathological mechanism is still unclear. Therefore, it is of great significance to construct appropriate animal models, especially those similar to human RA, in the study of the pathogenesis and clinical treatment of RA. There are many strains and method of rats and mice to construct the rheumatoid arthritis model. In this paper, we review the rEPORted mature and stable rat and mouse models related to RA.