Cardiovascular diseases constitute the largest burden to health worldwide. Ischemic heart disease seriously harms the physical and mental health of sufferers and its morbidity and mortality continue to increase. Coronary artery bypass grafting is a treatment for ischemic heart disease that can effectively rebuild the blood flow of the heart, but it has the problem of an insufficient long-term patency rate for venous grafts. Stable animal models can provide tools to investigate venous bypass graft diseases. This article summarizes the establishment and application of animal models of venous bypass graft disease to stimulate new ideas for research.