Asthma is a common chronic respiratory inflammatory disease. Additional asthma-related pathophysiology research and new drug trials are needed. This would be greatly expedited using corresponding animal asthma models. However, to date, there is no ideal model that can represent all the characteristics of the complex disease of human asthma. Therefore, this review provides the characteristics of commonly used animals currently used to make asthma models, different modeling method , different selected reagents, and the time required for modeling, which should help researchers in choosing appropriate animals, Methods and allergens.