Objective To explore the joint action of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) on the healing of tibia fractures in rats. Methods Forty-eight clean grade mature male SD rats were randomized in four groups, and a right middle tibia fracture was induced in each rat. Each group received bFGF and PDGF at different timepoints. Two to four weeks after the fractures were induced, six randomly selected rats from each group were sacrificed, and blood samples were taken from the femoral artery. Gross observations and histological observations were performed, and radiographs and additional specimens were taken. The levels of ALP, VEGF, BMP-2, and IGF-1 were measured at different observation points. Results Each period after operationt, analysis of the gross specimens showed that the size, density, imaging score, and trabecular bone index of the new bone tissue formed in groups A, B, and group C were significantly higher than in group D. The group that was treated with both growth factors exhibited higher levels of ALP, VEGF, BMP- 2, and IGF- 1 expression than the other three groups. Conclusions Local injection of exogenous bFGF or PDGF can accelerate fracture repair , and the effect of combined application is better than that of single application. The elevated expression of VEGF, BMP-2, and IGF-1 promoted by the two factors may represent one of the mechanisms involved in this process.