Objective A mouse model of alcoholic cardiomyopathy was established with liquid feed, which provided a good animal model to study alcoholic cardiomyopathy. Methods Sixteen-week-old C57BL/ 6 mice ( n = 21 alcohol group, n = 9 alcohol-free group) were fed with liquid feed with or without alcohol. The alcohol concentration in the feed was gradually increased from 4. 8% to 5. 4% for 8 weeks, and weight and mortality were monitored. Echocardiography and pathology were performed after 8 weeks. Results The weights of the alcohol feeding group began to decrease by the second week. Compared with the control group, body weight was significantly reduced. In addition, seven mice (33. 3%) died during the alcohol feeding period, whereas none of the mice in the control group died. The result of cardiac ultrasounds showed that the mice in the alcohol group had significantly thinner anterior and posterior ventricles, larger ventricular diameters, and the ejection fraction and shortening rate of the short-axis of the mice were significantly decreased. The heart / body mass indexes of mice in the alcohol group were significantly larger than those of the control group, and HE staining confirmed that the hearts of the mice in the alcohol group were significantly enlarged. Conclusions After 8 weeks of feeding with alcoholic liquid feed, the hearts of mice showed significantly larger and thinner left ventricular walls and cardiac dysfunction. Therefore, this method can be used to successfully establish a mouse model of alcoholic cardiomyopathy.