Objective To examine the effect of a compound Chinese medicine prescription (provided by theBeijing Hongtianli pharmaceuticals)on the lung injury induced by influenza virus A/ PR/8/ H1N1 in mice. Methods Ninetyfemale BALB/ c mice were randomly divided into six groups: normal control group, virus control group, Amantadinehydrochloride group, and compound Chinese herbal medicine high dose group, medium dose group and low dose group (n=15 in each group). After intragastric administration of the drugs for 2 days, the infection model of influenza virus A/ PR/8/H1N1 was established in mice by an intranasal challenge; the normal control group was injected with saline. Four hours later,each group was intragastrically administrated with different doses of medicine or saline, which were continuously given oncedaily for 5 days. The lung index of BALB/ c mice in each group was calculated on the 5th day of infection, thehemagglutination titer of lung tissue homogenate was measured, and the pathological changes of the lung tissue was observed.Results Compared with the virus control group, the lung index in the Amantadine hydrochloride group and the medium dosecompound Chinese medicine dose group was significantly decreased ( P < 0. 01). This index was also decreased in the low andhigh dose herbal compound groups ( P < 0. 05). The lung tissue viral hemagglutination titer was significantly decreased ( P <0. 01) in mice of all drug groups. The pathological changes in lung tissues in mice of all drug groups to a different degree.Conclusions The compound Chinese medicine prescription used in this study decreases the mean lung index and mean hemagglutination titer, and also improve the repair of lung injury in mice infected with influenza A/ PR/8/ H1N1.