Objective To explore the effects of a Chinese medicine, “Fujiu plaster” (developed by the AffiliatedHospital of Liaoning University of Traditional Chinese Medicine), on NGF/ TrKA and related inflammatory factors inasthmatic mice and its mechanism of action. Methods Fifty SPF adult BALB/ c mice were randomly divided into fivegroups: control, asthma model, dexamethasone, high-dose Fujiu plaster, and low-dose Fujiu plaster groups. To establishthe asthma model, the mice were sensitized through intraperitoneal injection of ovalbumin (OVA) and an asthmatic reactionwas provoked through ultrasonic aerosol inhalation. Expression of IL-4, total IgE, OVA-specific IgE, and IFN-γ in serumwas quantified by enzyme-linked immunosorbent assay. Pathological changes were examined using hematoxylin and eosin,and Masson trichrome staining. NGF and TrKA protein expression in the lung tissues was determined usingimmunohistochemistry. Results Compared with the control group, the model group exhibited significantly increasedexpression of NGF, TrkA, IL-4, total IgE, and OVA-specific IgE ( P < 0. 05), but decreased IFN-γ expression ( P <0. 05). Compared with the model group, the dexamethasone and high-dose Fujiu plaster groups exhibited significantlyreduced expression of NGF, TrkA, IL-4, total IgE, and OVA-specific IgE ( P < 0. 05), and increased IFN-γ expression( P < 0. 05). No significant changes to the aforementioned indicators were observed in the low-dose Fujiu plaster group ( P > 0. 05). Conclusions Fujiu plaster inhibites the secretion of IL-4 and IgE, and promotes the secretion of IFN-γ bydownregulating expression of NGF and TrkA proteins to regulate the imbalance of Th1/ Th2 lymphocytes, thus relieving the asthma attack.