Genetic quality control of laboratory animals is important for laboratory animal production, scientificresearch, and the biomedical industry. However, problems with the genetic quality of laboratory animals have continued fora long time, because it has hysteresis and concealment. The major professional groups working with laboratory animals areanimal experimenters, supervisors, and administrators. Based on the possible problems with genetic quality in theproduction of and experiments on laboratory animals, combined with practical experience of animal management and animalexperiments for scientific research, this paper analyzes the possible causes of these problems, and provides advice andsolutions for these to be applied, during the training of professionals and the teaching of medical students. Througheducation, theoretical explanations, and examples in the training and teaching processes, as well as strengthening theunderstanding of the importance of genetic quality control among professionals, the aim is to guarantee the genetic quality oflaboratory animals and improve the authenticity and accuracy of animal experiments. This paper also provides a reference for non-technical personnel to discover, analyze and solve the genetic quality of experimental animals.