Objective To compare the effects of two hemostatic methods including 3M vetbond tissue adhesiveand electrocoagulation in a rat model of uremia. Methods Male SD rats were divided into groups A and B. To induce theuremia model, all rats underwent right and 2/3 left kidney resection. 3M vetbond tissue adhesive was used in the group Afor hemostasis, while electric coagulation was used in group B. The amount of bleeding and the duration of left renal bloodflow blockage during operation were assessed. The postoperative survival rates of the two groups were compared. Thecreatinine values of all rats after operation were measured, and rats for which the creatinine value was two to three timeshigher than normal were further regarded as a uremic model. Kidney tissues were examined by pathology. Results Theserum creatinine after the application of both hemostatic method after 5/6 renal resection was 2-3 times higher than thenormal level. Left renal blood flow blockage of group A was (59. 97 ±7. 56) s and that of group B was (174. 1±15. 28) s( P <0. 05). The blood loss of the group A during left renal resection was (0. 11±0. 037) mL, and that of group B was(0. 24 ±0. 056) mL ( P <0. 05). Pathology of renal tissues in both groups indicated glomerular ischemic shrinkage andtubular interstitial fibrosis. The postoperative survival rate of group A was significantly higher than that of the group B ( P <0. 05). Conclusions 3M vetbond tissue adhesive is more effective than electrocoagulation to shorten the bleeding time,decrease the bleeding amount, or increase the postoperative survival rate.