Objective To investigate the inhibitory effect of Shenyi capsules combined with 5-FU on the growth and angiogenesis of colon cancer and its possible mechanism. Methods Fifty BALB/ c mice with LoVo colon cancer were randomly divided into five groups: model group, 5-FU group, Shenyi capsule low-dose group, Shenyi capsule high-dose group, and Shenyi capsule+5-FU group. Differences in disease indicators were compared. Results 1) The Shenyi capsule high-dose and Shenyi capsule+5-Fu groups had the highest inhibition rate, and with the extension of administration time,the inhibition was more marked. (2) The thymus mass, thymus index, spleen mass and spleen index of the Shenyi capsule +5-FU group were improved significantly ( P <0. 05). (3) The inhibitory effect in the Shenyi capsule+5-FU group on MVD was the most obvious, followed by the Shenyi capsule high-dose group and low-dose group. An inhibitory effect of Shenyi capsule+5-FU group on the MVD of tumor was not observed. (4) Compared with the model group, the metastasis rates in various organs in the high dose Shenyi capsule group and Shenyi capsule+5-FU group were significantly lower ( P <0. 05).(5) Compared with the model group, the expressions of Gli1 protein and VEGF protein were decreased significantly ( P <0. 05) in the Shenyi capsule high-dose group and Shenyi capsule+5-FU group. Conclusions Shenyi capsule inhibits the growth and angiogenesis of colon cancer cells, and VEGF may be its main target.