Objective This study aimed to investigate the egg quality and nutritional components of domesticated Tibetan chicken in Guangzhou and compare them with those of with Wuhei chicken. Methods Various detection methods were employed to analyze the egg quality and nutritional components of domesticated Tibetan chicken in Guangzhou and Wuhei chicken. Results There was no significant difference in physical quality indicators of the eggs from those two chickens( P > 0. 05). There was no notable difference in the content of crude protein, crude fat, crude ash, and carbohydrate of those two kinds of eggs ( P > 0. 05). The contents of selenium, iron, and zinc of domesticated Tibetan chicken eggs in Guangzhou were significantly higher than those of Wuhei chicken eggs ( P <0. 05). The concentrations of pyridine ( P <0. 01), pyridine borane ( P <0. 05), and dodecane ( P <0. 05) in the domesticated Tibetan chicken eggs in Guangzhou were markedly lower than those in Wuhei chicken eggs, whereas the contents of 1-hexadecene, 14-methylpentadecanoate,methyl linoleate, methyloleate, and methyl stearate in the domesticated Tibetan chicken eggs in Guangzhou were significantly higher than those in Wuhei chicken eggs ( P <0. 05). Conclusions The contents of crude protein, crude fat, selenium, iron, and zinc and methyloleate in domesticated Tibetan chicken eggs in Guangzhou are higher than those in Wuhei chicken eggs.