Objective To study the effects of morroniside on the expression of the HGF and vWF of the ischemic ipsilateral cortex 7 days after ischemia reperfusion. Methods 25 male Sprague-Dawley rats were subjected to MCAO model with modified Zea Longa's method, then randomly divided into sham group (n=5), ischmia group (n=5), and morroniside groups (low, medium, and high dosage groups, n=5). Morroniside were then administered intragastrically once a day at dose of 30 mg/kg, 90 mg/kg and 270 mg/kg after operation. The expression of HGF and vWF of the ischemic ipsilateral cortex were detected by western blotting and Immunofluorescence 7 days after ischemia-reperfusion. Results Compared with the sham group, the expression of HGF in ischemia group increased significantly (P < 0.01) 7 days after MCAO. Compared with the ischemia group, the expression of HGF in the morroniside groups (30 mg/kg, 90mg/kg, 270 mg/kg) showed significant increased (P < 0.05, P < 0.01, P < 0.001). Compared with the sham group, the expression of vWF in ischemia group increased significantly (P < 0.001). Compared with the ischemia group, the expression of vWF in the morroniside groups (90 mg/kg, 270 mg/kg) showed significant increased (P < 0.01, P < 0.001). Conclusion Morroniside could increase the expression of HGF and vWF in the ischemic ipsilateral cortex, romoting the process of angiogenesis in focal cerebral ischemia rat.