As a vital component in an overall laboratory animal care and use program, development of a disaster plan plays a critical role for every research institution. Currently, most of domestic institutions would draw up an "emergency operation plan, EOP", but ignoring a practicable "business continuity plan, BCP" in establishing a disaster plan. In this article, we will discusse about the definition of disaster, how to set up an EOP, and how to establish a thorough BCP, in order to show an integrated and professional disaster plan in laboratory animal care and use program.