The generation of oxidative stress is closely associated with the occurrence and development of liver injury induced by chronic alcohol consumption. It is widely considered that oxidative stress is the major mechanism of alcoholic liver disease has become a research hotspot. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic insults. Nrf2 may play an important role in the metabolism and detoxification of a variety of drugs and chemical compounds. Deficiency of Nrf2 may aggravate the oxidative stress and damage homeostasis of redox system, resulting in cell toxicity, dysfunction, and even death. In this article we will review the research progress of Nrf2 in alcoholic liver injury models.