ObjectiveTo explore the relationship between gene expression of Cricetulus barabensis TYR gene family and Cricetulus barabensis coat color. Methods The relative expression quantity of TYR, TYRP1 in Cricetulus barabensis of different colors was analyzed by using real time quantitative PCR in this research. ResultsThe relative expression quantity of TYR, TYRP1 in Cricetulus barabensis respectively were 2.5,5.3 times than that in the Albino mutant, all results were corrected by the household gene. Conclusion The findings indicated that gene expression level of TYR gene family in Cricetulus barabensis were higher than that in the Albino mutant, and the gene expression level of TYR gene family were related with phenotype of Cricetulus barabensis coat color.