Objective To develop a mice model of type 2 diabetes mellitus(DM) by high fat diet with low dose streptozotocin(STZ).Methods\ Male C57BL/6J mice at 5 weeks of age were randomly divide into conventional diet(n=8),conventional diet with STZ(n=8),high fat diet(n=8) and high fat diet with STZ group(n=8).After the exposure to conventional or high fat diet for 5 weeks,mice were injected intraperitoneally with 100 mg/kg of either STZ or vehicle solution during fasting state,and kept on the same diet for the next 4...