Objective To develop a proper animal models representing human diabetes,the efficiency and doses of alloxan in male and female animals was investigated.Methods Alloxan were administered to beagle dogs and mice with different dosage.Blood glucose was tested after treatment at the 3rd,7th,14th,and 21th day,respectively.Results The different effects of alloxan on the blood glucose concentration was showed in female and male animals.After identical doses of alloxan injected,the blood glucose concentration in fe...