Objective To evaluate the efficacy for 4 disinfectants in inactivation of mouse hepatitis virus(MHV).Methods According to the 'Disinfectants Technical Guidelines',2002 ed,neutralization and MHV inactivation tests were used to evaluate their antiviral activity.Results After treatment with MHV-A59 for 5 min and 10 min,the inactivation logarithmic value of peracetic acid disinfectant,iodophor,sodium dichloroisocyanurate were higher than 4.The inactivation logarithmic value of benzalkonium bromide was lower than 4,indicating a low inactivation efficacy,which could not satisfy the requirements of guidelines.Conclusion Peracetic acid disinfectant,iodophor and sodium dichloroisocyanurate have good efficacy in inactivation of MHV-A59.