Objective To establish an animal model of pulmonary edema in piglets in order to serve the study on mechanisms and treatment of pulmonary edema.Method 20 piglets were randomized into control group(A) and model group(B),10 piglets in each group.Oleic acid 0.15 mL/kg was injected slowly into the animals in group B.The pathological changes of the lung tissue were examined,the lung water contents(LWC) and the ratio of lung wet weight(LWW) to lung dry weight(LDW) were calculated.Results The LWC,and the ratio of LWW to LDW in group B was significantly higher than that in group A(P<0.05).Conclusion An oleic acid-induced animal model of pulmonary edema in piglets has been successfully established.The pulmonary histopathological changes in this model are in accordance with the typical changes of pulmonary edema.It may provide an excellent animal model for studies on mechanisms and treatment of pulmonary edema.