The family of ErbB tyrosine kinase receptors can transmit signals derived from growth factor of epidermal growth factor family.There are four members in the ErbB tyrosine kinase receptor family: ErbB1,ErbB2/HER2/neu,ErbB3 and ErbB4.ErbBs play an essential role in the development of embryonic heart and maintaining cardiac function of adult heart.Conditional ErbB2 mutant mice provide an animal model for the major side effect,cardiomyopathy and heart failure, which can be observed in some patients undergoing chemotherapy with Trastuzumab and has revealed the important role of ErbB2 in normal heart function and ErbB2 function as an essential co-receptor of ErbB3 and ErbB4.Furthermore,ErbB2/4 heteromers transmit neuregulin-1 signals in the developing and adult heart.ErbB receptors are known regulators of many signaling cascades,such as those involving ras/mitogen-activated protein kinase,phosphatidylinositol-3 kinase /Akt,phospholipase C and calcium-dependent kinase.