Objective To establish an ischemia model in gerbil and investigate the changes of SOD and MDA concentration in the brain of ischemic animal.Method 72 adult gerbils were chosen and right common carotid artery were ligated to make cerebral ischemia model.The animals died with cerebral ischemia or anesthetized were anatomized.The vessels on the ventral surface of the brain were studied under a microscope and the content of water,SOD and MDA in brain were determined.Results Anatamization results show that there are 4 anatomical patterns of anterior communication arteries(ACA) and 3 anatomical patterns of posterior communication arteries(PCoA) in 72 experimental gerbils.The value of MDA and SOD in ischemic gerbils are all higher than that in control and sham operation animals.Conclusion Cerebral ischemic model of Mongolian gerbil can be made by ligating right common carotid artery and the change of SOD and MDA in this model is different from the model of ischemia-reperfusion.