Objective To investigate the protective effect of recovered SARS monkeys and vaccinated monkeys on the Infection of SARS-CoV. Methods To analyze changes of anti-SARA-CoV neutralization antibody, viral detection and pathological changes in lungs of monkeys from groups of SARS recovered monkeys, vaccinated monkeys and SARS model monkeys. Results Groups of SARS recovered monkeys, vaccinated monkeys produced high titer of neutralization antibodies, and inhibited the replication of the virus to a certain extent. The pathological changes of groups of SARS recovered monkeys and vaccinated monkeys were lighter than that in the SARS-monkey group. Conclusions Both groups of SARS recovered monkeys and vaccinated monkeys showed resistance to infection of SARS-CoV