Objective To study the characteristic issues of anesthesia management on auxiliary liver transplantation. Methods 26 healthy dogs were operated to establish an auxiliary liver transplantation model under general anesthesia and trachea intubation. Mean arterial pressure and heart rate were monitored by external jugular vein and common carotid artery cannulation. Arterial blood samples were taken, before and 15 minutes after aorta blocking and 15 minutes after aorta opening, for blood gas analysis. Results No anesthetic death occurred among all the 13 cases during operation period. The apparent hemodynamic fluctuation of recipient dogs was observed during the period of abdominal aorta blocking and opening. Metabolic acidosis also took place during this period. Apparent rise of blood potassium was detected during reperfusion period. Conclusion In order to improve the survival rate, it is important to actively maintain the stability of hemodynamics, acid-base balance and correct electrolyte disturbance.