Objective To investigate the severity of early injuries and pathological changes of liver, kidney and small intestines in rats with severe burn at plateau.Methods Forty eight Wistar rats with 30% full thickness burn were randomly divided into 6 groups(n=8) and another 8 healthy Wistar rats as control group.The liver,kidney and small intestine were harvested for histopathological examination at 3,6,12,24,48 and 72 hours after burning.Resulte The injury of multiple organs in rats was obvious at 3 h post-burn and became severe at 48 h-72 h post-burn.Conclusion The injuries of multiple organs,especially the liver,kidney and small intestine in rat with severe burn at plateau occur early and last for a long time.This condition of injuries are of a direct correlation with the influence of hypoxic environment at plateau.