Objective To question whether No-1886, a synthetic compound, decreases plasma glucose and free fatty acids or improves pathological changes in diabetic Guizhou Minipigs induced by high sucrose and high fat feed. Methods 15 Guizhou Minipigs about 3-4 months were randomly divided into 3 groups of normal control, diabetes, diabetes treatment, which were fed by basal diet,high sucrose and high fat feed or with 1.0% No-1886 respectively.The concentration of plasma glucose and free fatty acids of minipigs,which were fasting the previous night,were analyzed in the 0,2,3,4,5,6,8th month respectively.These minipigs were put to death at the end of 8th month, liver pathologic changes were observed under microscope after the small lumps of liver were fixed with formalin and stained with Oil Red O or liver glycogen (PAS). Results The high plasma glucose and free fatty acids were observed one month late and gradually increased in the diabetes group but not in normal control group(P<0.05).The plasma glucose and free fatty acids of diabetes treatment group were lower than those in diabetes control group. The normal liver structure and abundant glycogen were observed in the treatment group. There were obvious liver fatty degeneration, many fat bubbles, local soluble necrosis, infiltration of a few lymphocytes and little or no glycogen in diabetes group. Conclusion No-1886 improved lipid metabolic disorder and liver fat pathological changes,and decreased plasma glucose or liver glycogenolysis.No-1886 may be developed as an agent to treat glucose metabolic disorder or lipid disorder in diabetes.