SHRSP rat is the model animal for spontaneously hypertension and stroke, and is cultivated through selective mating and secondary inbred. The incidence of cerebral apoplexy is higher than 90%, and the animals would display cerebral hemorrhage or cerebral infarction, the peri-focus blood vessle walls thickening and in hyaline degeneration, increased renin activity and molecular weight. And raised blood pressure is a prerequisite to cerebral apoplexy occurrence and development. The HFC burden test showed 5.9-9.7 times higher concentration of total cholesterol, severe nephrosis and appearance of renal glomerulus foam cells. The foam cells rose with hypertension continuation. The permeability of lipid rose as the capillary of kidney was damaged following hypertension, and hyperlipemia facilitated the development of nephrosis. The sclerosis of renal glomerulus was accompanied with increased foam cells, whose characteristic of the distribution pattens of human and rat was indentical. It is suggested that SHRSP rat can be used as the model for human disease.