Objective To compare the KM mice growth, development, propagation and disease in two groups.Methods 0.04% multivitamin, 0.02%vitamin E and 0.05% cod liver oil were added in pellet stuff of experiment group, and no vitamin in control group. Results Higher pregnancy rate and larger litter size were observed in experiment group, while more young mice lost and disease fuffering were showed in control group. Conclusion Unless KM mice get different kinds of vitamins on top of enough protein, fat, carbohydrate, their production and propagation will reduce seriously.