Objective To evaluate influences of treated dose adriamycin (ADR) on heart function and trace element content of left ventricular tissue and protective effect of taurine (Tau) on rabbit myocardium. Methods The pure New Zealand rabbits were assigned randomly to adriamycin (ADR) group(n=9),control group(n=9) and ADR Tau group (n=8).Rabbits of ADR group received an injection of ADR (2mg/kg, i.v.) once a week.For 8 weeks of experiment, rabbits of control group were similarly injected with saline.Rabbits of ADR Tau group received an injection of ADR (2 mg/kg.i.v.) once a week and from the third week the rabbits received Tau(200mg/kg, per os) once a day. Heart rate (HR),cardiac output (CO), blood pressure (BP),ferrum(Fe) and magnesium(Mg) of left ventricular tissue were examined 3 weeks after last time of injection. Results CO and BP were significantly decreased in the ADR group compared with the control group (P<0.01). BP was significantly decreased in the ADR tau group compared with the control group(P<0.01). The content of Fe and Mg in control group was significantly higher than that of ADR group (P<0.05,P<0.01).The Fe content of ADR group was significantly lower than that of taurine-treated group (P<0.05). Conclusion Heart function is decreased by treated-dose ADR injection. Tau would play a protective role on rabbit myocardium.