Advances in the pathogenesis of abnormal copper metabolism disorder in Parkinson's disease
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1.Encephalopathy Center,The First Affiliated Hospital of Henan University of Chinese Medicine;2.The First Clinical College of Medicine,Henan University of Chinese Medicine

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    Abstract:

    Parkinson's disease is a neurodegenerative disease associated with abnormal copper metabolism in the brain,which leads to misfolding and aggregation of α-synuclein-copper complexes, which is an important pathological sign of Parkinson's disease. Copper metabolism refers to the cellular metabolic process involving copper ions, which is closely related to the pathogenesis of α-synuclein aggregation, dopamine metabolism, mitochondrial dysfunction, oxidative stress and iron death in Parkinson's disease. In this review, we describe the molecular metabolic mechanism of copper toxicity by studying the pathological role of copper metabolism in Parkinson's disease,in order to provide evidence and help for further improvement of the mechanism of action and drug development.

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History
  • Received:April 29,2024
  • Revised:June 11,2024
  • Adopted:September 19,2024
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