Application and prospect in experimental animal model of chronic stress
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1. Institute of Microcirculation &2.Basic Medical College, Hebei North University, Zhangjiakou 075000, China;3.2. Hebei Key Laboratory of Acute and Severe Disease Pathogenesis and Intervention, Shijiazhuang &4.Zhangjiakou, 050017 &5.075000;6.3. Basic Medical College, Hebei Medical University, Shijiazhuang 050017

Fund Project:

Hebei Province graduate student innovation ability training funding project

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    Abstract:

    The effect and mechanism of chronic stress on psychosomatic diseases is a hot topic in the field of stress research. The establishment of animal models to simulate human chronic stress state is of great significance in the principle of stress response, the pathogenesis of related diseases, clinical treatment and drug development. In this paper, the commonly used animal models of chronic stress at home and abroad were reviewed, the classification of stressors, animal selection, model construction, pathological manifestations and evaluation indexes were summarized, and the advantages and disadvantages and application progress of various models were discussed, hoping to provide references for the study of model selection of chronic stress response.

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History
  • Received:October 07,2023
  • Revised:March 03,2024
  • Adopted:March 20,2024
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