TRP channel is a non-selective cation channe. In recent years, a large number of studies have found that TRP channels take participate in variety of cardiovascular diseases, and the study on mitochondrial function regulation by TRP channel and its relationship with cardiovascular diseases has become a research hotspot. Up to date, the relative references are mainly focused on TRPV, TRPM and TRPC channels. This review focuses on above TRP channels in the regulation of mitochondrial function and their relationship with cardiovascular diseases.