Liver is the most common organ that tumors spread to, and expression of miRNA is very important in the process of liver metastasis. In this study, research progress of related miRNAs in regulating liver metastases from digestive system malignant tumors was collated and analyzed. Through searching related literature, this paper provides an introduction to the role of miRNAs in liver metastasis of colorectal cancer, gastric cancer, pancreatic cancer and gallbladder cancer, which helps with the diagnosis, treatment and research of tumor liver metastasis.