Renal function is to filter blood , regulate fluid and electrolyte balance, which is crucial for health of the body, moreover, the kidney is susceptible to toxicity of various compounds in and out of the body, resulting in renal function damage, hence the prevention and treatment of renal function injury caused by various factors is also a hot research topic. Zebrafish is an ideal animal model as it is closely related to humans in terms of morphology, physiology and function of kidney and its response to compounds. In this paper, we will review the methods and evaluation indexes of zebrafish kidney injury modeling.