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Research progress on the role of autophagy in the pathogenesis of systemic sclerosis
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Affiliation:

1.Baotou Medical College,Inner Mongolia University of Science Technology;2.Central Laboratory of the First Affiliated Hospital of Baotou Medical College (Key Laboratory of Autoimmunity of Inner Mongolia Autonomous Region);3.The First Affiliated Hospital of Baotou Medical College

Fund Project:

Supported by the National Natural Science Foundation of China; Supported by Natural Science Foundation of Inner Mongolia Autonomous Region; Science and Technology Planning Project of Inner Mongolia Autonomous Region

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    Abstract:

    【Abstract】 Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular lesions and skin fibrosis, which can cause structural and functional damage to multiple organs. The pathogenesis of SSc is complex, which may be related to genetic, environmental factors and abnormal immune mechanisms. Autophagy is an evolutionarily conservative process of self degradation in the body, which can participate in the pathogenesis of body immunity and autoimmune diseases through a variety of pathways. This article mainly reviews the research progress on the role of autophagy in the angiopathy and fibrosis of SSc through regulating immune cells and mediating signal pathways.

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History
  • Received:February 01,2023
  • Revised:April 17,2023
  • Adopted:December 04,2023
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