Research progress in the mechanism of microRNA regulation in diarrhea-predominant irritable bowel syndrome and traditional Chinese medicine interventions

doi:10.3969/j.issn.1671-7856.2024.12.015

Home > Archive>Volume 34, Issue 12, 2024 >127-135. DOI:10.3969/j.issn.1671-7856.2024.12.015

Research progress in the mechanism of microRNA regulation in diarrhea-predominant irritable bowel syndrome and traditional Chinese medicine interventions
DOI:
                        10.3969/j.issn.1671-7856.2024.12.015
                    
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Author:
                        HE Changhui1HE Changhui
1. the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
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PAN Haidi1PAN Haidi
1. the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
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DOU Xin1DOU Xin
1. the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
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MEI Xiao1MEI Xiao
1. the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
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DENG Hualiang2DENG Hualiang
2. Second Department of Gastroenterology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014
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WANG Wei2WANG Wei
2. Second Department of Gastroenterology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014
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Affiliation:1. the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China. 2. Second Department of Gastroenterology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014
Clc Number:R-33
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Abstract:

The incidence of diarrhea-predominant irritable bowel syndrome (IBS-D) remains high, with microRNA (miRNA)-mediated intestinal barrier dysfunction, visceral hypersensitivity, low-grade inflammation, and dysbiosis playing significant roles in its pathogenesis. Traditional Chinese medicines can treat IBS-D by directly or indirectly targeting miRNAs to regulate multiple pathways and targets in a coordinated manner. This article systematically reviews the involvement of miRNAs in the pathogenesis of IBS-D and the progress of traditional Chinese medicine interventions. It explores the relationship between traditional genetics, epigenetics, and the Chinese medicine concepts of ‘kidney’ and ‘spleen’ in terms of congenital and acquired interactions from a molecular biology perspective. This review thus provides a reference for exploring the micro-material basis of the ‘Zang-Xiang’ theory of traditional Chinese medicine, and offers new ideas and method for the effective treatment of IaBS-D using traditional Chinese medicine.

Key words:diarrhea-predominant irritable bowel syndrome(IBS-D); miRNA; mechanism of action; traditional Chinese medicine; research progress

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Received:July 30,2024
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Online: March 05,2025
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