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Home > Archive>Volume 34, Issue 12, 2024 >117-126. DOI:10.3969/j.issn.1671-7856.2024.12.014
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Research progress on the role of exosomal microRNAs in methamphetamine-induced neurotoxicity and drug development
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1. Electron Microscopy Laboratory, Research and Experimental Center, Kunming Medical University, Kunming 650500, China. 2. School of Forensic Medicine, NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming 650500. 3. Department of Human Anatomy, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500

Clc Number:

R-33

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    Abstract:

    Methamphetamine(METH) is a new type of abused drug with a strong central stimulant effect. Its excitatory pathway involves a series of central higher-level functions, including drug-related rewards and motivation, learning and memory, decision-making, and execution. METH not only causes neurotoxicity, but its long-term use may also cause cognitive dysfunction, loss of personality, and may lead to serious social violence in addicts. Exosomes, as a novel cell-to-cell carrier, are involved in the occurrence and development of drug addiction, and exosome microRNAs are important biomarkers for METH addiction and are also involved in various aspects of METH-induced neurotoxicity. Eoxosmes may thus be useful therapeutic carriers providing a new approach for the diagnosis and treatment of METH abuse.

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History
  • Received:June 27,2024
  • Online: March 05,2025
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