Research advances in regulation of the hypothalamic-pituitary-adrenal/ hypothalamic-pituitary-thyroid/hypothalamic-pituitary-gonadal axes in the treatment of depression by traditional Chinese medicine
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Affiliation:

1. College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan 063210, China. 2. Hebei Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Diabetes and Its Complications, Tangshan 063210

Clc Number:

R-33

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    Abstract:

    The pathogenesis of depression is complex and treatment method are currently limited, and it is therefore important to clarify its pathogenesis and develop new therapeutic drugs. Hormones and hormone-modifying compounds have been used to treat depression, and their therapeutic effects are attributed to regulation of the peripheral endocrine system and their effects on non-endocrine circuits in the central nervous system. The hypothalamic-pituitary adrenal (HPA)/hypothalamic-pituitary-thyroid (HPT)/hypothalamic-pituitary-gonadal (HPG) axes are closely related to the pathogenesis of depression. The mechanism of action of traditional Chinese medicines in the treatment of depression is extensive, and the three axes are regulated in a variety of ways. Based on new evidence of hormones and hormone operon compounds involved in the pathology and treatment of depression, this review summarizes the relevant mechanisms of current traditional Chinese medicine in the treatment of depression, to provide new ideas and references for traditional Chinese medicine research.

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History
  • Received:February 23,2024
  • Online: March 05,2025
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