Research progress on the role of microglia efferocytosis in Alzheimer’s disease

doi:10.3969/j.issn.1671-7856.2024.11.020

Home > Archive>Volume 34, Issue 11, 2024 >163-168. DOI:10.3969/j.issn.1671-7856.2024.11.020

Research progress on the role of microglia efferocytosis in Alzheimer’s disease
DOI:
                        10.3969/j.issn.1671-7856.2024.11.020
                    
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Author:
                        MA Chiyuan1,2MA Chiyuan
1. Department of Brain Disease Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China. 2. the First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000
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WANG Xinzhi1WANG Xinzhi
1. Department of Brain Disease Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
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LIU Xiangzhe1LIU Xiangzhe
1. Department of Brain Disease Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
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HAN Zhenzhen3HAN Zhenzhen
3. Zhengzhou Jinshui District General Hospital, Zhengzhou 450000
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GUO Ming4GUO Ming
4. Zhengzhou Weilai Road Street Elder Care Center, Zhengzhou 450000
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LIU Haofei1LIU Haofei
1. Department of Brain Disease Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
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LI Xiao5LI Xiao
5. Henan University of Chinese Medicine, Zhengzhou 450046
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Affiliation:1. Department of Brain Disease Center, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China. 2. the First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450000. 3. Zhengzhou Jinshui District General Hospital, Zhengzhou 450000. 4. Zhengzhou Weilai Road Street Elder Care Center, Zhengzhou 450000. 5. Henan University of Chinese Medicine, Zhengzhou 450046
Clc Number:R-33
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Abstract:

Microglia efferocytosis, the process by which microglia phagocytose damaged and dead cells, has anti inflammatory and pro-damage repair effects. Recent studies have shown that microglia efferocytosis plays a crucial role in the pathogenesis of Alzheimer’s disease (AD) and may be a novel therapeutic target for AD. This paper reviews the relationship between microglia efferocytosis and AD pathogenesis and the potential of using efferocytosis-related molecules as therapeutic targets for AD. The aim of this review is to provide new ideas and approaches for the treatment of AD.

Key words:microglia; efferocytosis; Alzheimer’s disease; cognitive impairment; neuroinflammation

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Received:May 06,2024
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Online: January 03,2025
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